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26 mai 2023 – Séminaire BMBI par Cédric Laurent

Cédric Lau­rent (MCF HDR, CNRS UMR 7239 LEM3 – Uni­ver­sité de Lor­raine, Nan­cy, France) don­nera un séminaire 

 le ven­dre­di 26 maide 14h à 15h à l’am­phi Gauss (Cen­tre de recherche de Royallieu)

Titre du sémi­naire : « Defin­ing a scaf­fold for ante­ri­or cru­ci­ate lig­a­ment: What has been done, and what still needs to be done? »

Résumé : Tis­sue engi­neer­ing is a promis­ing alter­na­tive to cur­rent sur­gi­cal meth­ods for the repair of lig­a­ments, and in par­tic­u­lar the ante­ri­or cru­ci­ate lig­a­ment (ACL) which is asso­ci­at­ed with extreme­ly fre­quent injuries. How­ev­er, despite the wide vari­ety of scaf­folds that have been pro­posed for lig­a­ments since the 2000s, tis­sue engi­neered solu­tions have nev­er reached the stage of clin­i­cal appli­ca­tion. The ques­tion of how to pro­pose a scaf­fold that meets the many require­ments of tis­sue engi­neer­ing of lig­a­ments is still large­ly open. In this pre­sen­ta­tion, the syn­the­sis of sev­er­al years of research car­ried out in Nan­cy on ACL tis­sue engi­neer­ing is pro­posed, with empha­sis on the devel­op­ment, fab­ri­ca­tion, char­ac­ter­i­sa­tion and then opti­mi­sa­tion of a fibrous scaf­fold. The inter­est of extend­ing the char­ac­ter­i­za­tion to the evo­lu­tion of scaf­fold prop­er­ties after implan­ta­tion will also be empha­sized, as well as the need to con­sid­er the future anchor­ing of the scaf­fold with­in the bone tun­nels from the begin­ning of the pro­ce­dure. In par­tic­u­lar, com­pu­ta­tion­al sim­u­la­tion will be used as a sys­tem­at­ic tool to avoid a tri­al-and-error approach and pre­dict the prop­er­ties of the pro­posed scaf­folds. In con­clu­sion, a non-exhaus­tive list of the chal­lenges that remain to bring these devel­op­ments to clin­ics will be proposed.