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27 septembre - Séminaire du Pr David N. Ku

Le jeudi 27 septembre, BMBI reçoit le  Professeur David N. Ku (Georgia Institute of Technology, USA) pour le septième séminaire BMBI de l'année 2018. Ce séminaire est intitulé :

 The fastest bond in biology – Can save you or kill you!

Ce séminaire se tiendra dans l'amphi Gauss au Centre de Recherche de Royallieu de 13h à 14h

Résumé :  Arterial blood flow is critical to life.  With trauma, the blood must clot quickly or the body will exsanguinate.  With heart attack and strokes, blood clotting cuts off oxygen to the end-organ causing death.  Our hemodynamics studies show that white blood clots in arteries occur at very high shear rates capturing platelets using the fastest bond measured in biology (microseconds) at almost 100% efficiency.  The biophysical mechanism likely depends on the unusual longest protein in the body, von Willebrand Factor, more so than platelets that are actually a secondary player.  vWF morphs into efficient nets with exposure of 10,000X the bond sites only under pathologically high shear rates.  Platelet margination, previously thought to be crucial to white clot formation, is shown to be secondary by Lattice-Boltzman and experimental techniques.  The in silico and in vitro results are translated into in vivo clinical utility to develop new medical devices to control clotting.

Our recent direct numerical simulations based on coupled Langevin Dynamics and Lattice-Boltzmann method predicted the effects of charged domains on vWF A1 and platelet GPIb. The findings suggest totally new ways to create anti-thrombotic therapies. The physical simulations indicate that electrostatically charged particles can affect the tertiary state of vWF and can strongly affect the aggregation of platelets to occlusion in experiments.  Thus, our theories have resulted in a new class of nanobots as anti-thrombotic agents that are sensitive to hemodynamics, but do not exhibit pharmacological toxicity.  We have also discovered a new small molecule that causes rapid lysis of the occlusive thrombus. The talk will describe the use of physics to understand and prevent heart attacks and strokes.