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Squeezing Particles into a Constriction: AI-Based Data Analysis

Sci­en­tif­ic con­text – How do soft par­ti­cles squeeze through nar­row pores? This ques­tion is rel­e­vant to many appli­ca­tions in bio­log­i­cal flows, envi­ron­men­tal trans­port, and bio­med­ical microflu­idic devices. When deformable par­ti­cles flow through a con­stric­tion, their inter­ac­tions with the walls and with neigh­bor­ing par­ti­cles can lead to com­plex behav­iors, such as, col­li­sions, aggre­ga­tion and even­tu­al­ly clog­ging of the con­stric­tion. We study these phe­nom­e­na using ful­ly three-dimen­sion­al com­put­er sim­u­la­tions of flu­id-filled cap­sules, per­formed with our in-house soft­ware. By vary­ing key para­me­ters such as the applied flow, num­ber of par­ti­cles, par­ti­cle deforma­bil­i­ty and con­stric­tion width, we gen­er­ate large data-sets cov­er­ing a wide range of dynam­i­cal regimes.
Project objec­tive – The main goal of this project is to devel­op AI based tools for ana­lyz­ing and extract­ing auto­mat­i­cal­ly infor­ma­tion from these large sim­u­la­tion datasets. The stu­dent will inves­ti­gate machine learn­ing and com­put­er vision meth­ods to:
• auto­mat­i­cal­ly detect and track indi­vid­ual par­ti­cles,
• extract par­ti­cle tra­jec­to­ries and veloc­i­ties,
• iden­ti­fy par­ti­cle-par­ti­cle and par­ti­cle-wall inter­ac­tions,
• clas­si­fy dif­fer­ent dynam­i­cal regimes, such as pas­sage, and aggre­ga­tion,
• iden­ti­fy pat­terns link­ing sim­u­la­tion para­me­ters to the observed dynam­ics.
Required skills – This inter­dis­ci­pli­nary project com­bines com­pu­ta­tion­al physics, flu­id mechan­ics, data analy­sis, machine learn­ing and com­put­er vision. It offers an oppor­tu­ni­ty to work with large-scale sim­u­la­tion data and devel­op AI tools for ana­lyz­ing com­plex phys­i­cal sys­tems. Depend­ing on the stu­den­t’s inter­ests, the devel­oped meth­ods can also be applied to oth­er soft-par­ti­cle sys­tems, includ­ing exist­ing datasets of red blood cells flow­ing through microflu­idic channels.

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